Endocrine Abstracts

There is compelling evidence that certain families of endothelial cell-specific tyrosine kinases and their ligands (e.g. VEGFR/VEGF, Tie2/Ang) are essential for embryonic development and for angiogenesis in a wide variety of physiological and pathological circumstances. There is also evidence for a tissue-specific and tumor-specific regulation of endothelial cell growth and phenotype.We recently identified EG-VEGF, an endothelial cell mitogen with a unique selectivity, ess...